X-BODY Biosciences has developed an innovative therapeutic antibody discovery platform for the rapid generation of monoclonal antibodies by interrogation of human antibody libraries on live cells and deep sequencing. The human libraries employed in the platform capture the full diversity of the naïve antibody repertoire. X-BODY’s capability to employ live cells as targets enables functional selection strategies for the identification of activity-modulating antibodies against challenging membrane targets that cannot be presented in a functionally relevant soluble form, e.g., multi-spanning membrane targets like GPCRs and ion channels and heavily glycosylated targets. Deep sequencing capabilities allow for comprehensive, comparative analysis to identify rare antibodies with desired binding and functional properties. A proprietary Fv-based VL pairing process has led to highly soluble and stable IgGs. Functional soluble VHs can also be readily formatted into bi-specific or multi-specific therapeutic antibodies.